Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC073
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2023-01-16 11:01
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment the same th

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 9 individuals with a value less than 0.54 were subsequently diagnosed with PD. That is, 21.43% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.54 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 34, 'TN': 25, 'TP': 8, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 13, 'TN': 11, 'TP': 29, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 17, 'TN': 10, 'TP': 25, 'FP': 20}

Test Battery Details

Circle

numCircles 5
timePerCircleMean 36.768
timePerCircleCoV 0.762068
timePerCircleSlope 0.23738
meanError 1.29735
tremorFreq 7.03125
tremorRelPower 48.0664
tremorGyroAmpMean 0.0293273
tremorGyroAmpSlope 0.00313131
tremorGyroAmpCoV 0.50978
tremorCoordAmpMean 0.0362327
tremorCoordAmpSlope 0.00138637
tremorCoordAmpCoV 0.450797
tremorAccAmpMean 0.0355989
tremorAccAmpSlope 0.00254776
tremorAccAmpCoV 0.405456
tremorPcRelVar 0.703019
tremorPcX 0.687292
tremorPcY 0.726381

Circle Segment 1

Duration 24.56 s, Accuracy Estimate 1.444 (lower is better)

Circle Segment 2

Duration 19.8 s, Accuracy Estimate 1.011 (lower is better)

Circle Segment 3

Duration 18.64 s, Accuracy Estimate 0.87 (lower is better)

Circle Segment 4

Duration 85.48 s, Accuracy Estimate 1.825 (lower is better)

Circle Segment 5

Duration 35.36 s, Accuracy Estimate 1.336 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 49.1533
timePerSpiralCoV 0.206688
timePerSpiralSlope -0.0117882
meanError 1.70425
tremorFreq 7.03125
tremorRelPower 43.172
tremorGyroAmpMean 0.0273936
tremorGyroAmpSlope 0.00210052
tremorGyroAmpCoV 0.391587
tremorCoordAmpMean 0.0925144
tremorCoordAmpSlope 0.000324598
tremorCoordAmpCoV 1.14005
tremorAccAmpMean 0.0357955
tremorAccAmpSlope 0.00137495
tremorAccAmpCoV 0.357175
tremorPcRelVar 0.540373
tremorPcX 0.125707
tremorPcY 0.992067

Spiral Segment 1

Duration 56.68 s, Accuracy Estimate 1.521 (lower is better)

Spiral Segment 2

Duration 54.88 s, Accuracy Estimate 1.572 (lower is better)

Spiral Segment 3

Duration 43.28 s, Accuracy Estimate 1.821 (lower is better)

Spiral Segment 4

Duration 36.92 s, Accuracy Estimate 1.617 (lower is better)

Spiral Segment 5

Duration 40.84 s, Accuracy Estimate 1.933 (lower is better)

Spiral Segment 6

Duration 62.32 s, Accuracy Estimate 1.762 (lower is better)

Elel

eDurationMean 0.697179
eDurationStd 0.122291
eDurationStdnorm 0.175408
eDurationMedian 0.655
eDurationQuartdelta 0.12375
eDurationQuartdeltanorm 0.188931
eDurationKurt 6.52813
eDurationTrenddiff -0.055
eDurationTrendratio 0.919708
eWidthMean 2.988
eWidthStd 1.03535
eWidthStdnorm 0.346503
eWidthMedian 2.691
eWidthQuartdelta 1.2285
eWidthQuartdeltanorm 0.456522
eWidthKurt 4.71024
eWidthTrenddiff 0.117
eWidthTrendratio 1.04545
eHeightMean 6.807
eHeightStd 1.0706
eHeightStdnorm 0.157279
eHeightMedian 6.669
eHeightQuartdelta 1.5795
eHeightQuartdeltanorm 0.236842
eHeightKurt 2.84788
eHeightTrenddiff -0.117
eHeightTrendratio 0.982456
eAspectMean 0.437834
eAspectStd 0.125366
eAspectStdnorm 0.286332
eAspectMedian 0.403846
eAspectQuartdelta 0.165571
eAspectQuartdeltanorm 0.409987
eAspectKurt 3.29783
eAspectTrenddiff 0.0671296
eAspectTrendratio 1.18125
eSlantMean -0.276493
eSlantStd 0.250162
eSlantStdnorm -0.90477
eSlantMedian -0.266667
eSlantQuartdelta 0.322618
eSlantQuartdeltanorm -1.20982
eSlantKurt 2.53604
eSlantTrenddiff -0.0950067
eRtopMean 0.520778
eRtopStd 0.166161
eRtopStdnorm 0.319063
eRtopMedian 0.5
eRtopQuartdelta 0.272566
eRtopQuartdeltanorm 0.545131
eRtopKurt 1.98958
eRtopTrenddiff 4.94049e-15
eRbotMean 1.27556
eRbotStd 0.56318
eRbotStdnorm 0.441516
eRbotMedian 1.35714
eRbotQuartdelta 0.909167
eRbotQuartdeltanorm 0.669912
eRbotKurt 2.01612
eRbotTrenddiff 0.249091
eRrightMean 0.749603
eRrightStd 0.117893
eRrightStdnorm 0.157274
eRrightMedian 0.75
eRrightQuartdelta 0.143849
eRrightQuartdeltanorm 0.191799
eRrightKurt 3.29239
eRrightTrenddiff 0.0823413
eRleftMean 0.593481
eRleftStd 0.213324
eRleftStdnorm 0.359444
eRleftMedian 0.660377
eRleftQuartdelta 0.309997
eRleftQuartdeltanorm 0.469423
eRleftKurt 2.1129
eRleftTrenddiff 0.121053
lDurationMean 0.927564
lDurationStd 0.227278
lDurationStdnorm 0.245026
lDurationMedian 0.915
lDurationQuartdelta 0.26375
lDurationQuartdeltanorm 0.288251
lDurationKurt 6.22039
lDurationTrenddiff -0.085
lDurationTrendratio 0.910053
lWidthMean 3.765
lWidthStd 0.937873
lWidthStdnorm 0.249103
lWidthMedian 3.627
lWidthQuartdelta 1.25775
lWidthQuartdeltanorm 0.346774
lWidthKurt 2.36525
lWidthTrenddiff 0.351
lWidthTrendratio 1.1
lHeightMean 16.488
lHeightStd 1.80586
lHeightStdnorm 0.109526
lHeightMedian 16.497
lHeightQuartdelta 2.7495
lHeightQuartdeltanorm 0.166667
lHeightKurt 2.31317
lHeightTrenddiff -0.819
lHeightTrendratio 0.951724
lAspectMean 0.22747
lAspectStd 0.0487516
lAspectStdnorm 0.214321
lAspectMedian 0.228346
lAspectQuartdelta 0.0631262
lAspectQuartdeltanorm 0.276449
lAspectKurt 3.04118
lAspectTrenddiff 0.0276596
lAspectTrendratio 1.13448
lSlantMean -0.0934712
lSlantStd 0.113366
lSlantStdnorm -1.21284
lSlantMedian -0.103175
lSlantQuartdelta 0.16458
lSlantQuartdeltanorm -1.59516
lSlantKurt 2.5561
lSlantTrenddiff -0.0423186
lRtopMean 0.737402
lRtopStd 0.178353
lRtopStdnorm 0.241866
lRtopMedian 0.763158
lRtopQuartdelta 0.244755
lRtopQuartdeltanorm 0.320714
lRtopKurt 3.54741
lRtopTrenddiff -0.16129
lRbotMean 1.25011
lRbotStd 0.5858
lRbotStdnorm 0.468599
lRbotMedian 1.13889
lRbotQuartdelta 0.586663
lRbotQuartdeltanorm 0.515119
lRbotKurt 8.33853
lRbotTrenddiff 0.0944444
lRrightMean 0.837318
lRrightStd 0.181385
lRrightStdnorm 0.216626
lRrightMedian 0.888889
lRrightQuartdelta 0.178391
lRrightQuartdeltanorm 0.20069
lRrightKurt 5.54251
lRrightTrenddiff -0.148144
lRleftMean 0.492409
lRleftStd 0.161061
lRleftStdnorm 0.327089
lRleftMedian 0.512821
lRleftQuartdelta 0.21769
lRleftQuartdeltanorm 0.424495
lRleftKurt 2.34132
lRleftTrenddiff 0.147774

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.950439
sumTouchScores 19.9592
meanMovementTime 0.8915
numTouches 21
undershootPercentage 4.7619
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.930744
sumTouchScores 15.8227
meanMovementTime 1.19312
numTouches 17
undershootPercentage 5.88235
overshootPercentage 11.7647

ZigZag

numZigzags 5
timePerZigzagMean 52.248
timePerZigzagCoV 0.231397
timePerZigzagSlope 0.0678303
meanError 1.73353
tremorFreq 7.03125
tremorRelPower 39.0615
tremorGyroAmpMean 0.0344078
tremorGyroAmpSlope 0.00333139
tremorGyroAmpCoV 0.423475
tremorCoordAmpMean 0.051853
tremorCoordAmpSlope 0.00189359
tremorCoordAmpCoV 0.303454
tremorAccAmpMean 0.0463062
tremorAccAmpSlope 0.0023589
tremorAccAmpCoV 0.329915
tremorPcRelVar 0.691995
tremorPcX 0.651579
tremorPcY -0.758581

ZigZag Segment 1

Duration 50.52 s, Accuracy Estimate 1.562 (lower is better)

ZigZag Segment 2

Duration 52.04 s, Accuracy Estimate 1.55 (lower is better)

ZigZag Segment 3

Duration 42.72 s, Accuracy Estimate 1.53 (lower is better)

ZigZag Segment 4

Duration 43.4 s, Accuracy Estimate 2.097 (lower is better)

ZigZag Segment 5

Duration 72.56 s, Accuracy Estimate 1.929 (lower is better)

ZigZag Offset

numZigzags 4
timePerZigzagMean 21.12
timePerZigzagCoV 0.0644125
timePerZigzagSlope -0.0140152
zigzagHeightMean 64.3607
zigzagHeightCoV 0.0813121
zigzagHeightSlope 0.00819842
meanError 0.0573544
tremorFreq 6.93359
tremorRelPower 31.4942
tremorGyroAmpMean 0.0304444
tremorGyroAmpSlope -0.000366007
tremorGyroAmpCoV 0.412556
tremorCoordAmpMean 0.089863
tremorCoordAmpSlope -0.00158435
tremorCoordAmpCoV 0.548194
tremorAccAmpMean 0.0583854
tremorAccAmpSlope 0.00106355
tremorAccAmpCoV 0.427505
tremorPcRelVar 0.817287
tremorPcX -0.512893
tremorPcY 0.858453

ZigZag Offset Segment 1

Duration 22.28 s, Accuracy Estimate 0.072 (lower is better)

ZigZag Offset Segment 2

Duration 19.56 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 3

Duration 22.24 s, Accuracy Estimate 0.086 (lower is better)

ZigZag Offset Segment 4

Duration 20.4 s, Accuracy Estimate 0.038 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.67}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.54}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.7102559681652574}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9318399875212018}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6635103089489831}